The telomerase database

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August undefined, 2024

WebMay 2, 2008 · The Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments … WebInhibitors of poly(ADP-ribose) polymerase (PARP) have been shown to reduce the telomerase activity in cultured cells. To find out the specific member of the PARP family, which participates in the regulation of telomerase activity, in the present investigation, we knocked down the PARP-1 gene by siRNA in HeLa cells and studied the telomerase activity.

Telomerase Database Nucleic Acids Research Oxford …

WebMay 2, 2008 · The Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the phylogenetic relationship and structure, (iii) secondary structures of the RNA component and tertiary structures of various subunits of telomerase, (iv) mutations of … WebDec 11, 2007 · Search worldwide, life-sciences literature Search. Advanced Search Coronavirus articles and preprints Search examples: "breast cancer" Smith J cornerstone acres holly mi

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WebMay 18, 2024 · The same is true for the TeCK database that has been previously published as a collection of telomeric and centromeric sequences as well as telomerase, centromere and kinetochore binding proteins . The above-mentioned databases cover telomere related information but lack an annotation of genes with respect to the TM mechanism. WebMar 18, 2015 · While the Telomerase Database contains information about the telomerase, TeloPIN for the first time offers a resource where comprehensive information on experimentally validated telomere protein–protein, protein–DNA and protein–RNA interactions can be obtained through a user-friendly website, and an easily accessible … WebSep 16, 2024 · Telomere maintenance is key during cancer development. Malignant cells can either use telomerase or an alternative lengthening of telomere (ALT) pathway to maintain their telomere length. In Hodgkin’s Lymphoma (HL), the presence of telomerase activation is established. The activation of ALT has been reported recently. Our data … fanny hubert

DNA Primer Extension by Telomerase - Madame Curie …

The Telomerase Database — Arizona State University

WebIn the present work, we applied Mendelian randomization (MR) analysis to obtain estimates of the causal effect of telomere length (TL) on the risk of juvenile idiopathic arthritis (JIA) and JIA-associated iridocyclitis. Methods: Two-sample MR analysis was conducted using summary-level data from the largest genome-wide association studies ... WebDC is a disease of defective telomere maintenance, and patients with DC have premature telomere shortening and subsequent replicative senescence, leading to premature stem cell exhaustion and tissue failure. 5,6 Telomere maintenance is closely associated with life events, including aging and cancer predisposition, which is the reason why DC has been … fanny huthWebTelomeres act as caps that protect the internal regions of the chromosomes, and they're worn down a small amount in each round of DNA replication. In this article, we'll take a closer look at why telomeres are needed, why they shorten during DNA replication, and how the enzyme telomerase can be used to extend them. fanny hugerth

"WebTelomeres are DNA-protein complexes found at the ends of linear eukaryotic chromosomes. The telomeric complexes prevent the chromosome ends from being recognized and processed as double strand breaks (for a … " - The telomerase database

The telomerase database

Telomerase Database Nucleic Acids Research Oxford …

WebApr 14, 2024 · The telomere binding proteins RAP1 and TRF2 protect telomeres from engaging in homology directed repair (HDR). In this study, the authors reveal that the basic domain of TRF2 (TRF2B) and RAP 1 ... WebDec 11, 2007 · Figure 1. A snapshot of the TERT sequences page of the database. The TERT sequence table includes detailed information for each sequence, i.e. nucleotide length, GC …

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WebTelomerase Components. Either the telomerase complex or putative telomerase components have been identified in the following yeasts: S. cerevisiae, S. pombe, K. lactis, C. albicans ().Like telomerases from non … WebThe Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the …

WebCiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): Telomerase is a ribonucleoprotein enzyme that extends DNA at the chromosome ends in most eukaryotes. Since 1985, telomerase has been studied intensively and components of the telomerase complex have been identified from over 160 eukaryotic species. In the last two decades, … WebApr 10, 2024 · Canonical telomeres (telomerase-synthetised) are readily forming G-quadruplexes (G4) on the G-rich strand. However, there are examples of non-canonical telomeres among eukaryotes where telomeric tandem repeats are invaded by specific retrotransposons. Drosophila melanogaster represents an extreme example with …

WebTelNet. – a database of genes involved in telomere maintenance (TM) Telomere length maintenance is essential for the unlimited proliferation of human cancer cells due to the 3’-end erosion, a process intrinsic to the replication of linear chromosomes. Progressive telomere shortening in somatic cells leads to the induction of senescence or ... WebMay 18, 2024 · The different telomere maintenance (TM) mechanisms appear to involve hundreds of proteins but their telomere repeat length related activities are only partly …

WebThe Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the … fanny humbertWebNational Center for Biotechnology Information fanny humbert dermatologueWebDec 11, 2024 · Function. The main functions of a telomere are to maintain chromosomal stability and prevent chromosomal degradation. Additionally, telomeres protect ends of the chromosome from DNA end-joining to one … fanny hurtigWebSearch database Search term. Search. Advanced; Help; Home About Introduction Data authorities Names Clinical significance Review status HGVS expressions Data ... c.3184G>A (p.Ala1062Thr) AND Pulmonary fibrosis and/or bone marrow failure, Telomere-related, 1. Clinical significance: Likely benign ... fanny huiban ostéopatheWebJan 1, 2008 · The Telomerase Database is a useful resource especially for researchers who are interested in investigating the structure, function, evolution and medical relevance of … cornerstone ac plumbing tampaWebThe Telomerase Database provides comprehensive information about (i) sequences of the RNA and protein subunits of telomerase, (ii) sequence alignments based on the … fanny hussonWebThe Telomerase Database is a useful resource especially for researchers who are interested in investigating the structure, function, evolution and medical relevance of the telomerase cornerstone acs login