How does cisplatin enter the cell

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August undefined, 2024

WebNov 7, 2024 · In line with cell death critically depending on mtDNA-damage rather than nDNA-damage, apoptosis induction by cisplatin in testicular germ cell tumor cells does not require the nDNA-damage response ... WebOct 5, 2014 · Cisplatin becomes activated once it enters the cell. In the cytoplasm the chloride atoms on cisplatin are displaced by water molecules. This hydrolyzed product is a potent electrophile that can react with any nucleophile, including the sulfhydryl groups on proteins and nitrogen donor atoms on nucleic acids.

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Web† There is evidence of superior efficacy and reduced toxicity for cisplatin/pemetrexed in patients with non-squamous histology, in comparison to cisplatin/gemcitabine. Scagliotti GV, et al. Phase III study comparing cisplatin plus gemcitabine with cisplatin plus pemetrexed in chemotherapy-naïve patients with advanced-stage NSCLC. WebInside the cell, the neutral cisplatin molecule undergoes hydrolysis, in which a chlorine ligand is replaced by a molecule of water, generating a positively charged species, as … gpt 4 huggingface

Mechanism explaining the accumulation of cisplatin within the …

WebHowever, before cisplatin enters the cell it may bind to phospholipids and phosphatidylserine in the cell membrane. In addition, in the cytoplasm many potential … WebHow does cisplatin actually enter cells? Biology According to my lecture notes it cannot diffuse across membranes, but the recommended textbook for the course and wikipedia … WebSulfur-Containing Macromolecules Once inside the cell, cisplatin can interact with a variety of other molecules besides DNA—including two sulfur-containing macromolecules, metallothionein and glutathione, that sequester cisplatin and remove it from the cell. gpt 4 free access

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Cisplatin nephrotoxicity: a review of the literature

WebIf cisplatin is aquated and acquires a charge outside of the cell, it is likely that it enters the cell via OCT1, an organic cation transporter, or CTR1, a copper (I) transporter. [1] Both OCT1 and CTR1 transport charged species … gpt 4 how to useWebMar 1, 2006 · The detailed mechanism by which cisplatin kills cancer cells is still being actively studied, but apoptosis appears to play a central role. Resistance is a significant … gpt 4 image input

"WebTreatment of lung cancer, the most common type of carcinoma, is difficult due to disease progression at the time of diagnosis, causing a high mortality rate. 1 , 32 Cisplatin (DDP), also known as cis‐diaminodichloplatin, is a powerful nonspecific drug blocking the cell cycle. 33 , 34 DDP can enter cells through the passive transport. " - How does cisplatin enter the cell

How does cisplatin enter the cell

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WebApr 5, 2024 · Movement of cisplatin through the renal tubular cells is from a basolateral to apical direction. Two primary transporters are now known to be involved in transporting cisplatin into the tubular cells, the human … WebCisplatin is given into a vein (intravenously). You may have the chemotherapy drugs through: a cannula – a short, thin tube the nurse puts into a vein in your arm or hand a central line – a fine tube that goes under the skin of your chest and into a vein close by

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WebApr 12, 2024 · Progression-free survival (PFS) was 8 and 5 months in the cisplatin plus gemcitabine cohort and the gemcitabine cohort (p < .001), respectively. 4 Based on the phase 3 ABC-02 trial, cisplatin and gemcitabine have been the standard-of-care first-line therapy for metastatic or locally advanced biliary tract cancers (BTCs) for the past decade. WebThe present study aimed to examine whether AT-101 could increase the sensitivity of non-small cell lung cancer A549 cells to cisplatin (CDDP) and the underlying mechanisms. We evaluated the efficacy of the sequential treatment with AT-101 and CDDP using both in vitro and in vivo models.

WebApr 22, 2024 · Cisplatin delivers its attack by entering cancer cells and binding to and damaging DNA, which can lead to cell death. Cells respond to DNA damage by triggering DNA repair mechanisms that involve a number of proteins. Previous studies support that enhanced DNA repair seems to be the most likely cause of cisplatin resistance. WebNational Center for Biotechnology Information

WebMar 24, 2005 · Early studies suggested that cisplatin enters the cell mainly by passive diffusion, because its uptake proceeded linearly with time over 60 minutes and could not … WebCisplatin’s action inside the cell is familiar to anyone who took organic chemistry in college: it’s a nucleophilic substitution reaction (and remember, DNA is deoxyribonucleic acid). …

WebThe molecular pathways underlying cisplatin ototoxicity are still being investigated. Cisplatin enters targeted cells in the cochlea through the action of several transporters. Once it enters the cochlea, cisplatin is retained for months to years. It can cause DNA damage, inhibit protein synthesis, and generate reactive oxygen species that can ...

WebSep 1, 2024 · Cisplatin for injection is a cytotoxic drug. Follow applicable special handling and disposable procedures. 1 Reconstitution Reconstitute 50 mg vials with 50 mL of Sterile Water for Injection, USP. Each mL of the resulting solution will contain 1 mg of Cisplatin for injection. Reconstitution results in a clear or colorless to slight yellow solution. gpt 4 how to use imagesWebHow does cisplatin enter cells? 2. Is cisplatin actively extruded from cells, and if so how? 3. What are the cellular changes in acquired resistance associated with reduced gpt 4 is comingWebJan 1, 2024 · After cisplatin enters the cells, the chloride ligands are replaced by water molecules. This reaction results in the formation of positively charged platinum complexes that form covalent bonds with nucleophilic sites on guanine bases in a DNA strand using intrastrand and interstrand cross-links and create cisplatin–DNA adducts. gpt4 image searchWeb1 day ago · The number of drug shortages is forecast to reach a record level this year, imperiling patients. Cancer drugs in short supply include injectable cisplatin, methotrexate, and fluorouracil. Stocksy ... gpt 4 is freeWebJul 17, 2012 · Cisplatin, the most common platinum chemotherapy drug, was first approved in the US in 1978. It is particularly effective against testicular cancer, and is also used in … gpt4is still flawedWebSep 24, 2024 · Cisplatin (CDDP) is the drug of choice against different types of cancer. However, tumor cells can acquire resistance to the damage caused by cisplatin, generating genetic and epigenetic changes that lead to the generation of resistance and the activation of intrinsic resistance mechanisms in cancer cells. Among them, we can find mutations, … gpt4is impressive still flawedWebCisplatin is a chemotherapy drug that contains the metal platinum. It stops or slows growth of cancer cells and other cells that grow rapidly by damaging their DNA. FDA Approved … gpt 4 image processing