Draflazine
WebDraflazine. Draflazine is cardioprotective due to potentiation of receptor mediated effects of adenosine in the ischemic myocardium Andersen et al (1996), Bohm et al (1994). From: xPharm: The Comprehensive Pharmacology Reference, 2007. Related terms: … Web1 mag 1994 · Draflazine, at concentrations up to 100 mumol l-1, did not produce negative inotropic effects in atrial and ventricular myocardium. (-)-N6-phenylisopropyladenosine (R-PIA) and carbachol did not reduce force of contraction in ventricular myocardium, but exerted concentration-dependent direct negative inotropic effects in atrial myocardium.
Draflazine
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Web12 ore fa · Wellington Management segnala i rischi macroeconomici da tenere sotto controllo. Secondo Wellington Management potremmo essere giunti al punto in cui l’inasprimento delle condizioni di credito determinerà una recessione senza la necessità … WebNucleoside transport inhibition by draflazine was well tolerated by patients with unstable coronary disease. It seems to be a promising method of adenosine enhancement in acute myocardial ischaemia. The potential cardioprotective effect of the drug needs further …
WebDraflazine (R88021; (-)-R75231), is a potent nucleoside transporter ENT1 (SLC29A1) inhibitor with 370-fold selectivity over ENT2 (SLC29A2). R88021 exhibits 30- and 40-times higher affinity as (+)-R75231 (R88016) using calf lung membrane preparation (by … WebDraflazine is 20-times more potent as R88016 in enhancing adenosine potency against ADP-induced aggregation in human whole blood (IC50 = 0.5 μM vs 10 μM with 1 μM respective inhibitor), Draflazine and R75231, but not R88016, show cardioprotective efficacy against catecholamines infusion in rabbits in vivo.
WebDraflazine, a nucleoside transport inhibitor, was administered as a 15 min i.v. infusion of 2.5 mg to eight healthy male subjects. Plasma and whole blood concentrations were measured up to 32 h post-dose, and were related to adenosine breakdown inhibition (ABI) … WebDownload scientific diagram Evaluation of binding kinetics of reference compounds and the longest RT draflazine analogue at 10 °C. The assays have been performed on erythrocyte membranes with 4 ...
Web26 apr 2004 · Draflazine and dilazep were the most potent with K i values of less than 0.012 nM, followed by soluflazine and dipyridamole (Table 2). The least effective of the high-affinity inhibitors tested was NBTGR with a K i of 0.74±0.10 nM. Formycin B, a substrate for the es nucleoside transporter, had a K i of 139±35 μM (data not shown).
Web1 giorno fa · Noi non avevamo alcun dubbio, bastava dare un’occhiata ai dati in giro, analizzare bene, l’inflazione non poteva che scendere, quasi ovunque. Ma prima di iniziare, una chicca ve la mostriamo. Ben pochi vi aiutano ad analizzare e ragionare su questi … Continua a leggere → the cat is back b juniorWeb26 minuti fa · Goofynomics. L’economia esiste perché esiste lo scambio, ogni scambio presuppone l’esistenza di due parti, con interessi contrapposti: l’acquirente vuole spendere di meno, il venditore vuole guadagnare di più. Molte analisi dimenticano questo dato essenziale. Per contribuire a una lettura più equilibrata della realtà abbiamo aperto ... the cat is angry with themWebDraflazine (R88021; (-)-R75231), is a potent nucleoside transporter ENT1 (SLC29A1) inhibitor with 370-fold selectivity over ENT2 (SLC29A2). R88021 exhibits 30- and 40-times higher affinity as (+)-R75231 (R88016) using calf lung membrane preparation (by … tavr procedure for elderlyWeb1 giu 1999 · Anattractive feature of draflazine is that the specific target sitebinding characteristics can be determined easily by simultaneouslymeasuring plasma and whole blood concentrations of the drug. tavr procedure through groinWeb14 ore fa · Dall’UE norme antiriciclaggio più severe. Ranieri Razzante - Professore di legislazione Antiriciclaggio presso l’Università di Bologna. Nuove misure, più stringenti, contro il riciclaggio ... tavr procedure life expectancyWebMasayo Kamigaki is an academic researcher from Kyowa Hakko Kirin Co., Ltd.. The author has contributed to research in topic(s): Mechanism of action & Nucleoside. The author has an hindex of 1, co-authored 1 publication(s) receiving 3 citation(s). tavr procedure edwardsWebObjective: The pharmacokinetics and non-linear red blood cell partitioning of the nucleoside transport inhibitor draflazine were investigated in 19 healthy male and female subjects (age range 22–55 years) after a 15-min i.v. infusion of 1 mg, immediately followed by infusions of variable rates (0.25, 0.5 and 1 mg · h−1) and variable duration (2–24 h). Methods: The … the cat is back one-year course for juniors